Has anti-inflammatory, analgesic and antipyretic effects associated with inhibition of cyclooxygenase 1 and 2, regulate the synthesis of prostaglandins. Reduces aggregation, the adhesiveness of platelets and thrombus formation by inhibiting the synthesis of thromboxane A2 in platelets. Antiagregatsionnogo effect lasts for 7 days after a single dose (more expressed in males than in females).
Soluble in water, testrone tablet forms a buffer solution, which, after taking the drug supports the active substances in solution, preventing them from contact with acidic environment of the stomach to move back in undissolved form and precipitate as solids on its walls. The result is more rapid and complete absorption of the drug as well as its better tolerability in comparison with conventional tablets acetylsalicylic acid.
Moderately or weakly expressed pain syndrome in adults of different origin: headache (including associated with alcohol withdrawal syndrome), toothache, migraine, neuralgia, chest radicular syndrome, muscle and joint pain, pain during menstruation.
Increased body temperature in cold and other infectious and inflammatory diseases (adults and children over 15 years).
- Hypersensitivity to aspirin, other testrone, and components of the drug;
- zrozivno ulcerative lesions (exacerbation) of the gastrointestinal tract, gastrointestinal bleeding;
- expressed human liver or kidney;
- “Aspirin asthma”;
- hemorrhagic diathesis (hemophilia, von Willebrand disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);
- dissecting aortic aneurysm;
- portal hypertension;
- deficiency of vitamin K;
- deficiency of glucose-6-phosphate dehydrogenase, phenylketonuria:
- pregnancy (I and III trimester), lactation.
The drug is not indicated for children under 15 years old with acute respiratory infections caused by viral infections, because of the risk of Reye syndrome (encephalopathy and acute fatty liver with development of acute liver failure).
Be wary – hyperuricemia, urate nefroligiaz, gout, peptic ulcer and / or duodenal ulcer (in history), dekompepsirovannaya heart failure.
Dosing and Administration
The drug is intended for adults and children over 15 years.
Inside, adults and children over 15 years: Take 1 tablet (500 mg) to 6 times a day. In severe pain and high temperature – 2 tablets (1 g); the maximum daily dose should not exceed 6 tablets (3 g). Older adults: take 1 tablet (500 mg) to 4 times per day; the maximum daily dose should not exceed 4 tablets (2 g). How to use: dissolve the tablet / tablets in a glass (200 ml) of water or juice. The frequency and reception time interval between doses of the drug should be at least 4 hours. Regular adherence of the drug to avoid a sharp increase in temperature and decrease in pain intensity. The duration of treatment (without consulting a doctor) should not exceed 5 days when administered as an analgesic, and more than 3 days – as an antipyretic.
In the recommended doses, the drug is generally well testrone tolerated. The following side effects may occur in rare cases: