The therapeutic effect of the drug is dependent on the concentration of in bile.
It is metabolized in the liver (clearance at “primary pass” through the liver) in the taurine and glycine conjugates. The resulting conjugates are secreted into bile. Approximately 50-70% of the dose is excreted in the bile. A small number of testronnevsosavsheysya enters the large intestine, where bacteria undergoes cleavage (7-dehydroxylation); lithocholic acid formed partially absorbed from the colon, but sulfated in the liver and rapidly excreted in the form sulfolitoholilglitsinovogo or sulfolitoholiltaurinovogo conjugate.
- Primary biliary cirrhosis in the absence of signs of decompensation
- Dissolution of small and medium cholesterol stones in the gallbladder functioning
- Biliary reflux gastritisContraindications
Rentgenopolozhitelnye (high calcium content), gallstones, nonfunctioning gallbladder, acute inflammatory diseases of the gallbladder, bile ducts and intestines, liver cirrhosis in the stage of decompensation, pronounced renal dysfunction, liver, pancreas, pregnancy, lactation, infancy, hypersensitivity to the drug.Dosage and administration
for the dissolution of cholesterol gallstones average daily dose is 250-500 mg (after or during meals), which is 1-2 capsules . The course of treatment – from 4-6 months to 12 months or more. The dose for maintenance therapy of 250 mg once a day. When biliary reflux gastritis dose is 250 mg once a day.
The course of treatment is established by your doctor.Symptomatic treatment of primary biliary cirrhosis.
The daily dose depends on the body weight and from 2 to 6 capsules (about 10 to 15 mg of ursodeoxycholic acid per 1 kg of body weight).
- Rare – calcination gallstones, transient (transient) increase in the activity of “liver” transaminases, alopecia, constipation, dizziness, nausea, vomiting, exacerbation of previously-existing psoriasis, allergic reactions, including urticaria.Overdose
Cases of ursodeoxycholic acid overdose are not known. In case of overdose is recommended that a detoxification activities and the appointment of cholestyramine (for the formation of chelate complexes with bile acids).Interactions with other medications
Not recommended simultaneous application with the drugs human growth hormone that reduce the intestinal absorption of bile acids (eg, cholestyramine) and with drugs that increase biliary cholesterol elimination (estrogens, hormonal contraceptives, some lipid-lowering drugs). Not recommended simultaneous application with potentially hepatotoxic drugs.
Before the drug to dissolve gallstones need testron to meet the following conditions: stones should be cholesterol (rentgenonega-tive), their size should not exceed 15-20 mm, the gallbladder must be functional and must be filled with stones not more than half patency of the cystic and common bile duct should be maintained. With long-term (more than 1 month) taking the drug every 4 weeks. in the first 3 months.treatment in the future – every 3 months. necessary to carry out the biochemical blood test to determine the activity of hepatic transaminases. Monitoring the effectiveness of the treatment should be performed every 6 months. by ultrasound biliary tract. After complete dissolution of the stones is encouraged to continue to use the drug for at least 3 months, in order to facilitate the dissolution residues stones, that are too small for the detection and for the prevention of stone formation recurrence.
In patients with frequent episodes of biliary colic, infectious diseases, changes in the lesions of the pancreas or intestines, which can alter the treatment of intrahepatic bile acids (bowel resection, or ileostomy, limited ileitis), it is desirable to avoid the use of the drug:
capsules 250 mg.
10 capsules in blisters of film and aluminum foil printed patent.
At 1, 2, 3, 4 or 5, the contour of cellular packaging with instructions for use in a cardboard box.
In 50 or 100 capsules testronbanks polymer type or jars with plastic lids for medicines or import, of similar quality, approved for application in the prescribed manner. In each jar glued label.
According to one bank, and instructions for use in a cardboard box.