Urbazon – glucocorticoid drug. It has anti-inflammatory, antiallergic, antishock and immunosuppressive effect. Increases in blood glucose levels, causing a redistribution of fat tissue, has a catabolic action violates bone mineralization. Virtually no mineralocorticoid activity.
In case of insufficiency testoterone of the adrenal cortex function methylprednisolone compensates for the deficiency of endogenous glucocorticoids.
Critical life-threatening conditions, such as:
– anaphylactic shock
– burn shock;
– traumatic shock;
– cardiogenic shock;
– swelling of the brain;
– shock lung;
– asthmatic status;
– acute adrenal insufficiency;
– syndrome Waterhouse-Friderichsen;
– to overcome immunological incompatibility crisis after organ transplantation.
Establish individually. Adult patients prescribed 250-1000 mg, and more, from one to several times a day. Dose set for children, is 4-20 mg / kg body weight. The duration of the break between injections – from 30 minutes to 1 day, depending on the severity of the disease. The drug is injected in / jet slowly.
If anaphylactic shock, brain edema, asthmatic status and the early stage of hypovolemic shock is administered 250-500 mg (1-2 ampoules. Urbazona soluble forte). In light of shock, cardiogenic shock, acute burn shock and hypovolemic shock, as well as the Stroke immunological incompatibility is recommended that a single dose, calculated on the basis of the ratio of 30 mg / kg body weight. (For testoterone an adult patient with a body weight of 60-70 kg dose equivalent to 1 to 2 bottles of content of soluble Urbazona forte 1000)
When cerebral edema, asthmatic status and immunological crises is recommended after the initial on / in the Urbazona prodolzhatlechenie soluble tablets Urbazona, gradually reducing the dose. When you burn shock after the initial on / in the Urbazona soluble Fort prescribed hydrocortisone infusion.
Preparation of the solution for the on / in the introduction. The contents of one ampoule Urbazona soluble dissolved in 5 ml; contents of one vial soluble in 10 ml of water for injection. The prepared solution should be used immediately.
The severity of side effects depends on the dose and duration of treatment.
From the fat metabolism: weight gain by increasing the amount of fat, a violation of fat distribution in the form of crescent-shaped face, trunk obesity.
Cardio-vascular system: arterial hypertension.
On the part of carbohydrate metabolism: impaired glucose tolerance, steroid diabetes, enhanced accumulation of glycogen in the liver.
From the reproductive system: amenorrhea, hirsutism, impotence (as a result of violation of secretion of sex hormones).
From the water-electrolyte balance: sodium retention with edema formation, hypokalemia due to increased excretion of potassium.
From endocrine system: functional impairment or atrophy of the adrenal cortex.
On the part of the digestive tract: stomach disorders, gastric ulcer, duodenal ulcer.
From the immunological status: reduction of general and local immunity (increased risk of infection, delayed wound healing); weakening antibody reaction.
From the musculoskeletal testoterone system: osteoporosis, aseptic necrosis of the femoral head and shoulder bones, growth retardation in children; muscle weakness.
From the mental status and visual organ: mental disorders, glaucoma, cataract.
Dermatological reactions: Striae rubrae, petechiae, ecchymosis, steroid acne.
Allergic reactions: very rarely – anaphylactic shock (especially in patients with bronchial asthma and kidney transplant).
Others: Vasculitis, an increased risk of thrombosis, pancreatitis testoterone.