When parenteral administration is rapidly absorbed into the blood. The maximum concentration of drug in the blood (C max ) is reached in 15-30 minutes after intramuscular injection. .
The volume of distribution testostorone. The drug is distributed mainly in the aqueous phase (blood plasma). Not accumulates.
Excreted by the kidneys, mainly in the form of products of incomplete and complete oxidation of the partially unchanged.
intoxication with arsenic, mercury, bismuth, chromium, cardiac glycosides; hepatolenticular degeneration (Wilson-Westphal-Konovalov’s disease); chronic alcoholism (in the complex therapy), delirium tremens.
Hypersensitivity to the drug, hepatic insufficiency, hypertension, pregnancy, lactation, children under 18 years.
Dosing and Administration
Mostly intramuscularly or subcutaneously. When arsenic intoxication at the rate of 0.05 g / 10 kg, on the first day – 4.3 times, during the second day – 2.3 times, following – 1-2 times. When compounds of mercury poisoning – in the same way for 6-7 days. Treatment is carried out until the disappearance of symptoms of intoxication. When digitalis intoxication in the first 2 days is administered 250-500 mg (5.10 ml of an aqueous solution of 50 mg / ml) 3-4 times a day, then 1-2 times daily until termination cardiotoxicity.
When gepatotserebralnoy dystrophy – intramuscularly 250- 500 mg (5.10 mL of a solution of 50 mg / ml) daily or every other day; a course of treatment – 25-30 injections; if necessary, repeated after 3-4 months.
In chronic alcoholism administered 150-250 mg (3-5 ml of a solution of 50 mg / ml) 2-3 times a week. For relief of delirium – once 200-250 mg (4-5 ml of 50 mg / ml).
Side effects are
nausea, dizziness, tachycardia, paleness of skin. Allergic testostorone reactions are possible.
Overdose symptoms: shortness of breath, hyperkinesis, confusion, lethargy, stupor, intermittent convulsions (occur in excess of the recommended therapeutic dose of more than 10 times). Treatment:symptomatic therapy.
Interactions with other medicinal products
is not recommended simultaneous application unitiol with drugs, which contain heavy metals and alkalis, as there is a rapid expansion of unitiol.
In acute poisoning conduct additional therapeutic measures (gastric lavage, oxygen therapy, administration of dextrose, etc.).
The solution for intramuscular or subcutaneous administration of 50 mg / ml.
At 5 ml ampoules made of neutral glass. 5 vials are placed in blisters made of testostorone foil.
2 blisters with instruction on use and lancet ampulnam ceramic disc put in a pile of cardboard. When packing vials with a point or ring fracture scarifier not invest.